祝贺!刚刚中国神经科学学会-CST杰出神经科学家奖颁奖典礼:向不懈奔跑的神经科学家们致敬

来源: Cell Signaling Technology,Inc(China)   2019-10-12   访问量:1160评论(0)

自二十世纪以来,神经科学研究取得了飞速且长足的发展,神经系统可称为人体的“司令部”,研究“司令部”的运行机制和功能的重要性可想而知。由于科学家的不懈努力,神经科学研究近年来不断取得突破,接踵而至的新发现、层出不穷的新观点,似乎神经系统的迷雾正在渐渐散开,而伴随着这些发现,更大的挑战仍在眼前。我们的大脑活动与精神活动是如何联系的,随着社会老龄化,阿尔兹海默症等相关神经疾病能否被攻克,等等,这些或古老或神秘或严峻的问题,亟待科学家们的继续探索。

挑战犹在,而我们依然要为现下的成果鼓掌。



今年,CST与中国神经科学学会联合设立了CNS-CST杰出神经科学家奖,这是首次设立该奖项。在颁奖仪式上,主持人、中国神经科学学会副理事长王以政教授宣布,经过联合评选的过程,来自中国科学院神经科学研究所的杜久林研究和浙江大学医学院的李晓明教授获得了今年的奖项。


颁奖典礼:右一、中国神经科学学会理事长、浙江大学医学部主任段树民院士;右二、首届CNS-CST杰出神经科学家奖获奖者、中国科学院神经科学研究所杜久林研究员;左二、首届CNS-CST杰出神经科学家奖获奖者、浙江大学医学院李晓明教授;左一、CST亚太/中国总经理,全球副总裁董增军先生

CST亚太/中国总经理,全球副总裁董增军先生解释了设立该奖项的初衷。他调侃道,昨天来参会的路上一直回忆神经解剖课上关于十二对脑神经的顺口溜,“一嗅二视三动眼,四滑五叉六外展,七面八什么来着?…”曾经倒背如流怎么突然发现想不起来了呢?难道老年痴呆提前到来了吗?”引起了大家的共鸣。如今,神经系统疾病对大众已不是个陌生的词汇,例如阿尔兹海默症、帕金森疾病,不仅走入了影视剧(如电影“Still Alice”,2019热播剧“都挺好”), 和名人要客(如拳王阿里,里根,Michael J Foxs, 陈景润等), 也走入了我们大家更多普通家庭。面对这些病痛,身为科学家的自己却无能为力。


CST亚太/中国总经理,全球副总裁董增军先生在颁奖现场致辞

但如今,从发病机制的解析,到早期诊断标志物的寻找,再到药物研发的尝试,都能看到我们的科学家的身影。在科学发现后,如何造福人类,这中间的断层需要由创新转化连接。从科学发现,到高质量论文,如何最终转化为能够切实造福人类的成果,这些链条需要创新生态圈的催化。在创新转化的生态圈中,需要多方的合作(包括科学家,企业家,投资家等)。而CST发起该奖项的原因正缘于此:CST愿与科学家们携手共进,助推发现,共推转化。时代机遇,使命召唤,让我们共同努力!


杜久林研究员与董增军先生亲切合影

颁奖后,CNS-CST杰出神经科学家奖获奖人杜久林研究员介绍了自己一路以来的工作。他从零开始使用斑马鱼进行研究,目标是通过观察特定神经元的活动,回答斑马鱼中十万个神经元、一亿个突触的活动如何影响了斑马鱼的行为运动,从解析神经联接结构,到理清脑结构与和信号处理的规律,将帮助类脑智能技术的开发。

同时,杜久林研究员在大会中做了精彩的科研报告。


10月13日上午11:15-12:00,李晓明教授也将作为大会报告人与大家分享课题组的研究结果。敬请期待!


李晓明教授与董增军先生亲切合影

回首过去,神经研究一路荆棘密布,未来也可能一路坎坷,但科学家们不会放弃,Together, we go far,CST将永远为这些不懈奔跑的科学家加油、喝彩!


获奖者简介


杜久林,中国科学院上海生科院神经科学研究所研究员,感觉统合与行为实验室主任。1993年毕业于中国科技大学。1998年从中国科学院上海生理研究所(SHIP)毕业,获得博士学位。1999年至2000年,在上海生理研究所担任助理研究员。2000至2001年,在东京大学担任访问学者,2001年成为复旦大学副教授。2002年至2005年,成为加州大学伯克利分校分子与细胞生物学系的助理专家。2005年至今,开始任中国科学院上海生命科学研究院神经科学研究所研究员、博士生导师。他的研究主要涉及探究多模态感觉整合、行为以及神经血管耦合的机制。

研究成果和创建的斑马鱼在体研究技术处于国际领先水平,部分方法已在国际同行中广泛推广,在斑马鱼研究领域建立了良好的国际声誉。研究成果以通讯作者或第一作者形式发表在Nature、Neuron、Developmental Cell、PLoS Biology、Circulation Research、Nature Communications、Journalof Neuroscience、Cell Research、Cell Reports、PNAS 等国际学术期刊上。

近五年主要论著
通讯作者论文
1. Yao, Y.Y.#, Li, X.Q.#, Zhang, B.B.#, Yin, C., Liu, Y.F., Chen,W.Y., Zeng, S.Q., and Du, J.L.* (2016). Visual cue-specific dopaminergiccontrol of visuomotor transformation and
behavioral selection. Neuron 89(3): 598-612. (Featuredarticle).(代表论文)
2. Zhang, R.W.*, Li, X.Q.,Kawakami, K., and Du, J.L.* (2016). Stereotyped initiation of retinal waves bybipolar cells via presynaptic NMDA auto-receptors. Nature Communications 7:12650.(代表论文)
3. Zhang, B.B.#, Yao, Y.Y.#, Zhang, H.F., Kawakami,K., and Du, J.L.* (2017). Left habenula mediateslight-preference behavior in zebrafish via an asymmetrical visual pathway. Neuron 93(4): 914-928 (Featuredvideo abstract).(代表论文)

4. Du, W.J., Zhang, R.W.*,Li, J., Zhang, B.B., Peng, X.L., Cao, S., Yuan, J., Yuan, C.D., Yu, T.*, andDu, J.L.* (2018). The locus coeruleus modulates intravenous general anesthesia ofzebrafish via a cooperative mechanism. Cell Reports 24: 3146-3155.(代表论文)
5. Zhang, R.W.*, Du, W.J.,Prober, D., and Du, J.L.* (2019). Müller glial cellsparticipate in retinal waves via glutamate transporters and AMPA receptors. Cell Reports 27(10): 2871-2880.(代表论文)
6. Liu, T.T., Du, X.F.,Zhang, B.B., Yan, Y., Yin, J.A., Hou, H., Gu, S.Y., Chen, Q., Du,J.L.* Piezo1-mediated Ca2+ activities regulate brainvascular pathfinding during development. (Under review in Neuron)
7. Liu, J.N.#, Pan, L.M.#, Shang, C.F. #, Lu, B., Wu, R.J., Feng,Y., Chen, W.Y., Zhang, R.W., Bu, J.W., Xiong, Z.Q.*, Bu, W.B.*, Du, J.L.*, andShi, J.L.* A highly sensitive and selective nanosensor for near-infraredpotassium imaging. (Under review in Science Advances)
8. Shang, C.F.*, Wang,Y.F., Du, J.L.* (2019). Information integration for motor control. Current Opinion in Physiology8:116-120. (Invited review)
9. Chen, W.Y., Peng, X.L.,Deng, Q.S., Chen, M.J., Du, J.L.*, and Zhang, B.B.* (2019). Role of OlfactorilyResponsive Neurons in the Right Dorsal Habenula – Ventral InterpeduncularNucleus Pathway in Food-Seeking Behaviors of Larval Zebrafish. Neuroscience 404: 259-267.
10. Yin, C.*, Li, X.Q., andDu, J.L.* (2019). Optic tectal superficial interneurons detect motion in larvalzebrafish. Protein& Cell 10(4):238-248.
11. Jiao, Z.F.#, Shang, C.F.#*, Wang, Y.F.#, Yang, Z., Yang, C., Li,F.N., Xie, J.Z., Pan, J.W., Fu, L.*, and Du, J.L.* (2018). All-optical imagingand manipulation of whole-brain neuronal activities in behaving larvalzebrafish. Biomedical Optics Express 9(12): 6154-6169.
12. Du, X.F.*, Xu, B.,Zhang, Y., Chen, M.J., and Du, J.L.* (2018). A transgenic zebrafish model forin vivo long-term imaging of retinotectal synaptogenesis. Scientific Reports 8: 14077.
13. Zhang, Y.#, Xu, B.#, Chen, Q., Yan, Y., andDu, J.L.*, Du X.F.* (2018). Apoptosis of endothelial cells contributes to brainvessel pruning of zebrafish during development. Frontiers in Molecular Neuroscience 11:222.
14. Xu, B.#, Zhang, Y.#, Du, X.F., Li, J., Zi,H.X., Bu, J.W., Yan, Y., Han, H., and Du, J.L.* (2017). Neurons secretemiR-132-containing exosomes to regulate brain vascular integrity. Cell Research 27(7): 882-897 (Highlightedarticle)
15. Du, X.F.*, and Du,J.L.* (2016) A “death” trap for microglia. Developmental Cell 38(2): 120-121 (Invited Preview)
16. Zhang, R.W.*, and Du,J.L.* (2016). In vivo whole-cell patch-clamp recording in the zebrafish brain.Koichi Kawakami, Michael Orger and Elizabeth Patton (eds.), Methods in Molecular Biology 1451:281-291 (Invited BookChapter)
17. Shang, C.F., Li, X.Q.,Yin, C., Liu, B., Wang, Y.F., Zhou, Z.*, and Du, J.L.* (2015). Amperometricmonitoring of sensory-evoked dopamine release in awake larval zebrafish. J. Neurosci. 35(46): 15291-15294.
18. Li, J.*, Zhang, B.B.,Bu, J.W., and Du, J.L.* (2015). Intron-based genomic editing: a highlyefficient method for generating knockin zebrafish. Oncotarget 6(20):17891-17984. (Invitedreview)
19. Li, J.#, Zhang, B.B.#, Ren, Y.G., Gu, S.Y.,Xiang, Y.H., Huang, C., and Du, J.L.* (2015). Intron targeting-mediated and endogenousgene integrity-maintaining knockin in zebrafish using the CRISPR/Cas9 system. Cell Research 25(5):634-637.

非通讯作者论文
20. Feng, J.S., Zhang,C.M., Lischinsky, J., Jing, M., Zhou, J.H., Wang, H., Zhang, Y.J., Dong, A.,Wu, Z.F., Wu, H., Chen, W.Y., Zou, J., Hires, S.A., Zhu, J.J., Cui, G.H., Lin, D.Y., Du, J.L., Li, Y.L.*(2019). A genetically encoded fluorescent sensor for the rapid and specific invivo detection of norepinephrine. Neuron 102((4): 745-761.
21. Jin, W., Dai, Y.M., Li,F.N., Zhu, L., Huang, Z.B., Liu, W., Li, J.C., Zhang, M.J., Du, J.L., Zhang,W.Q., and Wen, Z.L.* (2019). Dysregulation of microglia function contributes toneuronal impairment in Mcoln1a-deficieint zebrafish. iScience 13: 391-401.
22. Zhang, R., He, J.,Wang, X., Pan, W., Cao, Y., Zu, Y., Jiang, Q., Du, J.L., Zhong, T.P.*(2019).Report of the Fifth Zebrafish Research Conference of China. Zebrafish 16(1):128-134.
23. Sun, F.M., Zeng, J.Z.,Jing, M., Zhou, J.H., Feng, J.S., Owen, S.F., Luo, Y.C., Li, F.N., Yamaguchi,T., Yong, Z.H., Gao, Y.J., Peng, W.L., Wang, L.Z., Zhang, S.Y., Du, J.L., Lin, D.Y.,Xu, M., Kreitzer, A.C., Gui, G.H., Li, Y.L.* (2018). A genetically-encoded fluorescent sensor enablesrapid and specific detection of dopamine in flies, fish, and mice. Cell 174(2): 481-496.
24. Tao, R., Shi, M., Zou,Y., Cheng, D., Wang, Q., Liu, R., Wang, A., Zhu, J., Deng, L., Hu, H., Chen,X., Du, J.L., Zhu, W., Zhao, Y., Yang, Y.* (2018). Multicoloured fluorescent indicatorsfor live-cell and in vivo imaging of inorganic mercury dynamics. Free Radic Biol Med. 121: 26-37.
25. Cong, L., Wang, Z.G.,Chai, Y.M., Hang, W., Shang, C.F., Yang. W.B., Bai, L., Du, J.L., Wang, K.*,and Wen, Q.* (2017). Tracking and whole brain functional imaging of a freelybehaving larval zebrafish. eLife 6:e28158.
26. Xu, D.J., Wang, B.,Zhao, X., Zheng Y., Du, J.L., and Wang, Y.W.* (2017). General anestheticsprotects against cardiac arrest-induced brain injury by inhibiting calcium wavepropagation in zebrafish. Molecular Brain 10:44.
27. Tao., R.K., Zhao, Y.Z.,Chu, H.Y., Wang, A.X., Zhu, J.H., Chen, X.J., Zou, Y.J., Shi, M., Liu, R.M.,Su, N., Du, J.L., Zhou, H.M., Zhu, L.Y., Qian, X.H., Liu, H.Y., Loscalzo, J., andYang, Y.* (2017). Genetically encoded fluorescent sensors reveal dynamicregulation of NADPH metabolism. Nature Methods 14(7): 720-728.
28. Poo, M.M.*, Du, J.L.,Ip, N., Xiong, Z.Q., Xu, B., and Tan, T.L. (2016). China brain project: basicneurosciences, brain diseases, and brain-inspired computing. Neuron 92(3):591-596 (NeuroView)
29. Xie, C., Zhang, Y.P.,Song L., Luo, J., Qi, W., Hu, J.L., Lu, D.B., Yang, Z., Zhang, J., Xiao, J.,Zhou, B., Du, J.L., Jing, N.H., Liu, Y., Wang, Y., Li, B.L., Song, B.L., andYan, Y.* (2016). Genome editing with CRISPR/Cas9 in postnatal mice correctsPRKAG2 cardiac syndrome. Cell Research 26(10): 1099-1111
30. Wang, M.S., Zhang,R.W., Su, L.Y., Li, Y., Peng, M.S., Liu, H.Q., Zeng L., Irwin, D.M., Du, J.L.,Yao, Y.G., Wu, D.D.*, and Zhang, Y.P.* (2016). Positive selectionrather than relaxation of functional constraint drives the evolution of visionduring chicken domestication. Cell Research 26(5): 556-573.
31. Li, Y.Y., Du, X.F.,Pei, G., Du, J.L., and Zhao, J.* (2016). β-Arrestin1 regulates morphology and dynamics ofmicroglia in zebrafish in vivo. Eur. J. Neurosci. 43(2):131-138.
32. Fan, W.P., Bu, W.B.,Zhang, Z., Shen, B., Zhang, H., He, Q.J., Ni, D.L., Cui, Z.W., Zhao, K.L., Bu,J.W., Du, J.L., Liu, J.N., and Shi, J.L.* (2015). X-ray radiation controlled NO-releasefor on-demand depth-independent hypoxic radiosensitization. Angew. Chem.Int. Ed. 127(47): 14232-14236.
33. Li, Y., Li, G.,Görling, B., Luy, B., Du, J.L., and Yan, J.* (2015). Integrative Analysis of CircadianTranscriptome and Metabolic Network Reveals the Role of De Novo Purine Synthesisin Circadian Control of Cell Cycle. PLoS Computational Biology 11(2):e1004086. (Coverstory)
34. Sang, Q., Zhang, J.,Feng, R., Wang, X., Li, Q., Zhao, X., Xing, Q., Chen, W., Du, J.L., Sun, S.,Chai, R., Jin, L., He, L., Li, H., and Wang, L.* (2014). Ildr1b is essentialfor semicircular canal development, migration of the posterior lateral lineprimordium, and hearing ability in zebrafish: Implications for a role in therecessive hearing impairment DFNB42. Human Molecular Genetics 23(23):6201-6211.
35. Liu, J.N., Liu, Y., Bu,W.B., Bu, J.W., Sun, Y., Du, J.L, and Shi, J.L.* (2014). Ultrasensitive nanosensorsbased on upconversion nanoparticles for selective hypoxia imaging in vivo uponnear-infrared excitation. J. Am. Chem. Soc. 136(27):9701-9709.
36. Li, H.S., Yue, R., Wei,B., Gao, G., Du, J.L., and Pei G.* (2014). Lysophosphatidic acid acts as anutrient-derived developmental cue to regulate early haematopoiesis. EMBOJournal 33(12):1383-1396.
37. Liu, J.N., Bu, J.W.,Bu, W.B.*, Zhang, S.J., Pan, L.M., Chen, W.P., Zhou, L.P., Peng, W.J., Zhao,K.L., Du, J.L., and Shi, J.L.* (2014). Real-time in vivo quantitativemonitoring of drug release by dual mode MR and UCL imagings. Angew. Chem. Int. Ed. 53(18): 4551-4555.

中文文章
38. 孙乐*, 李福宁, 杜久林* (2018). 大脑微观神经联接图谱研究进展与前景. 中国科学院科学发展报告21:82-90.
39. 孙乐*,李福宁,杜久林* (2018). 大脑神经联接图谱的研究进展. 中国科学:生命科学48(3): 253-265.
40. 张白冰*, 杜久林* (2017). 僵核结构和功能. 生理学报69(5): 623-636.
41. 杜久林*, 毕国强, 骆清铭, 徐富强, 方英, 王琛 (2016). 脑科学研究新技术. 中国科学院院报 31(7): 783-792.
42. 杜文杰, 杜久林, 喻田* (2016). 斑马鱼依托咪酯麻醉模型的建立. 生理学报68(3):301-305.
43. 许兵*, 张俞, 杜久林(2016). 血脑屏障研究进展. 生理学报 68(3): 306-322.
44. 尚春峰*, 穆宇, 杜久林* (2015). 以透明脑,观澄明心 - 斑马鱼神经功能研究进展.中国科学:生命科学45(3):223-236.
45. 杜旭飞*, 杜久林* (2015). 斑马鱼hypocretin/orexin 能神经系统的研究进展. 生命科学 27(7):827-836.
46. Li, J.*, and Du, J.L.*(2015). CRISPR/Cas9 技术在斑马鱼基因修饰中的应用. 生命科学 27(1):26-29.
47. 尚春峰*, 穆宇, 杜久林* (2014). 斑马鱼在神经科学研究中的应用. 生命科学年鉴3:141-170.


李晓明,浙江大学、多伦多大学教授,“长江学者”特聘教授,“十万计划” 中青年创新领军人才,杰出青年学者获得者。现任浙江大学医学院执行院长,浙江大学神经科学研究所执行主任,神经生物学系主任。2003年,毕业于第一军医大学,获得医学博士学位。多年从事临床神经疾病教学和科研工作,作为研究项目负责人,先后承担了国家自然科学基金重点项目、重大科研计划整合项目等。作为项目主要负责人,获得国家自然科学奖二等奖,省科技进步一等奖,中国医学科学二等奖,高等学校科研成果二等奖等。李教授主要探究关于突触和神经回路形成、维持以及调节的分子机制,从而为包括精神分裂症、自闭症和癫痫在内的神经精神疾病提供治疗策略。

近五年主要论著:

1. Dong P, Wang H, Shen XF, Jiang P, ZhuXT,Li Y, Gao JH, Lin S, Huang Y,He XB, Xu FQ, Duan S,Lian H, Wang H,Chen J, LiXM*. A novel cortico-intrathalamic circuit for flight behavior. Nature Neuroscience.2019 Jun;22(6):941-949.
2. Shen CJ,Zheng D, Li KX, Yang JM, PanHQ, Yu XD, Fu JY,Zhu Y,Sun P,Xie Y,Duan S,Hu H, Li XM*. Cannabinoid CB1receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbensmodulate depressive-like behavior. Nature Medicine. 2019 Feb;25(2):337-349.
3. Li Y, Li CY, Xi W, Jin S, Wu ZH, JiangP, Dong P, He XB, Xu FQ, Duan SM, Zhou YD, Li XM*. Rostral and Caudal VentralTegmental Area GABAergic Inputs to Different Dorsal Raphe Neurons Participate inOpioid Dependence. Neuron. 2019 Feb 20;101(4):748-761. e5.
4. Yang JM,Shen CJ, Chen XJ,Kong Y, LiuYS, Li XW, Chen Z, Gao TM, Li XM*. erbb4 Deficits in Chandelier Cells in theMedial Prefrontal Cortex Confer Cognitive Dysfunctions: Implications for Schizophrenia.Cerebral Cortex. 2018 Dec 22. doi: 10.1093/cercor/bhy316.
5. Cao SX, Zhang Y, Hu XY, Hong B, Sun P,He HY, Geng HY, Bao AM, Duan SM, Yang JM, Gao TM, Lian H*, Li XM*. ErbB4deletion in noradrenergic neurons in the locus coeruleus induces mania-likebehavior via elevated catecholamines. eLife.2018 Sep 4;7.pill:e39907.
6. Geng HY, Jing Z, Yang JM, Li Y, Wang N,Ye M, Chen XJ, Lian H and Li XM*. Erbb4 Deletion from Medium Spiny Neurons ofthe Nucleus Accumbens Core Induces Schizophrenia-Like Behaviors via ElevatedGABAA Receptor α1 Subunit Expression. Journal of Neuroscience, 2017 Aug 2;37 (31): 7450-7464.
7. Zhu JM, Li KX, Cao SX,Chen XJ,ShenCJ,Zhang Y,Geng HY,Chen BQ,Lian H,Zhang JM,Li XM*.Increased NRG1-ErbB4signaling in human symptomatic epilepsy. Sientific Reports. 2017 Mar10;7(1):141.
8. Pan G,Yang JM,Hu XY,Li XM*. Postnatal development of the electrophysiological propertiesof somatostatin interneurons in the anterior cingulate cortex of mice.Scientific Reports. 2016 Jun 20;6:28137.
9. Zhang Y,Cao SX,Sun P,He HY,YangCH,Chen XJ,Shen CJ,Wang XD,Chen Z,Berg DK,Duan SM, Li XM*.Loss of MeCP2 incholinergic neurons causes part of RTT-like phenotypes via alpha7 receptor in hippocampus.Cell Research. 2016 Jun;26(6):728-42.
10. Ni KM, Hou XJ,Yang CH, Dong P,LiY,Zhang Y,Jiang P, Berg DK, DuanS,and Li XM*. Selectively driving cholinergicfibers optically in the thalamic reticular nucleus promotes sleep. eLife. 2016Feb 11;5.pii:e10382.
11. Lu YM, Gao YP, Tao RR, Liao MH,Huang JY, Wu G, Han F,Li XM*. Calpain-dependent ErbB4 cleavage is involved inbrain ischemia-induced neuronal death. Molecular Neurobiology. 2016 May;53(4):2600-9.
12. Pan G, Li Y, Geng HY, Yang JM, LiKX,Li XM*, Preserving GABAergic interneurons in acute brain slices of miceusing the N-methyl-D-glucamine-based artificial cerebrospinal fluidmethod.Neuroscience Bull. 2015 Apr;31(2),265-70.
13. Chen C, Li HQ, Liu YJ, Guo ZF, WuHJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, GaoZ, DuanSM.A novelsizebased sorting mechanism of pinocytic luminal cargoes in microglia. Journal of Neuroscience. 2015 Feb 11;35(6):2674-88.



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